Marcus Rashford's two second-half goals caused Arsenal's first defeat of the season as Manchester United won 3-1 at Old Trafford after Antony scored on his United debut.
The Brazilian, who joined for £86m on Deadline Day from Ajax, made a dream start to life at United by scoring a first-half opener with a cool first-time finish (35).
Antony's goal came after Arsenal had been denied a 12th-minute opener by VAR after referee Paul Tierney used the pitchside monitor to disallow Gabriel Martinelli's clinical finish for a foul on Christian Eriksen by Martin Odegaard in the build-up to the goal.
Mikel Arteta's side deservedly levelled early in the second half when Bukayo Saka rolled home (60).
But United retook the lead just six minutes later as Rashford fired home from Bruno Fernandes' through-ball.
Rashford then scored his second with a breakaway goal set up by Eriksen in the 75th minute to secure a fourth consecutive victory for Erik ten Hag's side, who move up to fifth.
United are now three points behind leaders Arsenal as the Gunners' unbeaten start comes to an end with the north London side only a point ahead of Manchester City and Tottenham.